Program of ISW 2017

LIST OF POSTERS >>

DAY 1 Monday | 17^th July
Arrival day

14:00 – 16:00	Registration
16:00 – 18:00	Opening ceremony with Keynote Lectures Chair: Tamás Korcsmáros Burkhard Rost Technical University Munich, Germany Personalized health – harnessing the power of diversity Ruth Nussinov NIH National Cancer Institute, USA Oncogenic K-Ras signaling and drug discovery
18:00 – 20:30	Welcome reception and dinner
20:30 –	late Informal evening program (bowling, table football, swimming, etc.)

DAY 2 Tuesday | 18^th July

Omics approaches to signalling Chair: Gustav Sundell
09:00 – 09:30	Expert talk Federica Di Palma EI, Norwich, UK Evolution of tissue-specific regulatory programs in cichlids
09:30 – 10:00	Expert talk Nataša Pržulj UCL, London, UK Data-driven biomedical science
10:00 – 10:30	Expert talk Vera Van Noort University of Loewen, Loewen, Belgium Post-translational modifications and small peptides on the systems-level
10:30 – 11:00	Drinks break
Omics approaches to signalling Chair: Katri Vaparanta
11:00 – 11:30	Expert talk Gary Bader Toronto University, Toronto, Canada Using patient similarity networks and signaling pathways to predict clinical outcome
11:30 – 12:30	Selected talks Johannes Merilahti University of Turku, Turku, Finland Gamma-secretase mediated proteolysis is common for receptor tyrosine kinases Manjeet Kumar EMBL, Heidelberg, Germany Predicting novel substrates of PLK4 Hava Gil-Henn Laboratory of Cell Migration and Invasion, Bar-Ilan University Faculty of Medicine in the Galilee, Israel Differential regulation on invadopodia-mediated breast cancer metastasis by non-receptor tyrosine kinases Eszter Ari Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary MulEA – A tool for multi enrichment analysis
12:30 – 14:00	Lunch
Teamwork
14:00 – 14:30	Getting know each other through speed networking: project groups
14:30 – 16.00	Presenting the problem to be solved: project groups
16.00 – 16.30	Drinks break
16:30 – 18:30	Knights tournament and medieval team building activity
18:30 – 21:00	Feast at the Food Court
21:00 – 22:00	Poster session 1 (P-1 – P-10) Protein motifs and domains Systems medicine
22:00 –	late Informal evening program

DAY 3 Wednesday | 19^th July

Modelling signalling Chair: Orsolya Kapuy
09:00 – 09:30	Expert talk: Evangelia Petsalaki EMBL-EBI, Hinxton, UK Using phosphoproteomics-derived association networks to study the Fes kinase, a tumour-suppressive oncogene
09:30 – 10:00	Expert talk: Jasmin Fisher Microsoft Research, Cambridge, UK Deconstructing cancer signalling networks using executable biology
10:00 – 10:30	Expert talk: Balázs Papp Insitute of Biochemistry, Budapest, Hungary Underground metabolism and the predictability of evolution
10:30 – 11:00	Drinks break
Modelling signalling Chair: Scooter Morris
11:00 – 11:30	Expert talk: Andrei Zinovyev Institute Curie, Paris, France Network propagation for cancer data analysis
11:30 – 12:30	Selected talks Douglas Brubaker Massachusetts Institute of Technology, Cambridge, USA *The translation problem: mapping insights from experimental model systems to the human in vivo* context Mihály Koltai** Institut Curie – Centre de Recherche, Paris, France A data-driven logical model of colon cancer for biomarker and drug discovery Kristóf Szalay Turbine, Budapest, Hungary Constructing simulated cells Alexander Mazein European Institute for Systems Biology and Medicine, Lyon, France Comprehensive representation of disease-relevant signalling, metabolic and gene regulatory networks
12:30 – 14:00	Lunch
Teamwork
14:00 – 15:30	Discussing the problems to be solved: project groups
15:30 – 16:00	Drinks break
16:00 – 17:00	Discussing the problems to be solved: project groups
17:00 – 18:30	Excursion
18:30 – 21:00	Barbecue in the Pilis Forest
21:30 – 22:30	Poster session 2 (P-11 – P-19) Signaling resources Systems microbiology and therapy
22:30 –	late Informal evening program

DAY 4 Thursday | 20^th July

Chemoinformatics and signalling Chair: Malvika Sharan
09:00 – 09:30	Expert talk: Andreas Bender University of Cambridge, Cambridge, UK Chemical and biological data – from compound selection to mode of action analysis (and back again)
09:30 – 10:00	Expert talk: Attila Reményi Institute of Enzymology, Budapest, Hungary Signaling complexes: structure, function and drug design
10:00 – 10:30	Expert talk: Julio Saez-Rodriguez RWTH-Aachen University, Aachen, Germany Signaling networks models to understand and combat cancer: from clinical genomics to mechanistic modelling
10:30 – 11:00	Drinks break
Chemoinformatics and signalling Chair: Alexander Mazein
11:00 – 12:30	Selected talks Dezső Módos University of Cambridge – Department of Chemistry, UK Systems genomics of ulcerative colitis: combining GWAS and signaling networks identifies novel pathways in disease pathogenesis Alberto Calderone University of Rome “Tor Vergata”, Italy Investigating the role of network motifs in signaling network Fabian Froehlich Helmholtz Zentrum München, Neuherberg, Germany Large scale mechanistic modeling enables robust prediction of cancer cell drug response Jan Baumbach University of Southern Denmark, Odense, Denmark Systems medicine – network-enhanced disease profiling Anna Lovrics Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Mathematical modelling of epigenetic switches in cancer drug resistance Mohieddin Jafari Pasteur Institute of Iran, Tehran, Iran Rabies implicated signaling network; from static to dynamic modelling
12:30 – 14:00	Lunch
Teamwork
14:00 – 15:15	Working on presentations
15:15 – 16:30	Presentation of teams and discussion (10 minutes/team)
16:30 – 17:00	Drinks break
17:00 – 17:30	Discussing group presentations, novel ideas, and concrete actions (e.g. collaborations)
17:30 – 18:30	Closing Keynote: Toby Gibson EMBL, Heidelberg, Germany Regulation by molecular switching and its perturbation in disease
18:30 – 22:00	Award presention for teams and poster presenters, Closing remarks, Dinner
22:00 –	late Informal evening program with music

DAY 5 Friday | 21^st July
Departure day

List of posters

Poster session 1

Protein motifs and domains

P-1
Amanda Demeter
Quadram Institute, Norwich Research Park, Norwich, UK
Eötvös Loránd University, Budapest, Hungary
Mutational analysis of cell lines to uncover undesired changes in the regulation of autophagy

P-2
Tomer Meirson
Bar Ilan University, Safed, Israel
ABL kinase inhibitors reduce invadopodia-dependent invasiveness and consequent in vivo breast cancer metastasis

P-3
Neha Singh
Institute of Enzymology, Budapest, Hungary
Exploration of linear motifs through which MAPKs regulate other proteins

P-4
Gustav Sundell
Uppsala University, Uppsala, Sweden
Identification of phosphorylation switches of PDZ domain interactions using phosphomimetic phage display

P-5
Katri Vaparanta
University of Turku, Turku, Finland
The extracellular juxtamembrane domain of receptor tyrosine kinase ErbB4 is a major cleavage-independent determinant of ErbB4 JAK-STAT5 signaling selectivity

Systems medicine

P-6
Oyebode Oyeyemi
University of Manchester, Manchester, United Kingdom
A logical model of HIV-1 interactions with the T-cell activation signalling pathway

P-7
Orsolya Kapuy
Semmelweis University, Budapest, Hungary
A systems biological study of cellular life-and-death decision in Huntington’s disease

P-8
Bence Szalai
RWTH Aachen University, Aachen, Germany
Transcriptomics based inference of pathway activities in prostate cancer samples

P-9
Erin Oerton
University of Cambridge, Cambridge, United Kingdom
Analysis of disease relationships by integrating biological data types: A systematic evaluation

P-10
Iván Fekete
Semmelweis University, Budapest, Hungary
Computational prediction of personalized therapies in onco-hematological malignancies

Poster session 2

Signaling resources

P-11
Márton Ölbei
Earlham Institute, Norwich, United Kingdom
SalmoNet: an integrated multi-layer network for Salmonella

P-12
Marc Gouw
EMBL, Heidelberg, Germany
The eukaryotic linear motif database: 3000 valiated motif instances and more

P-13
Alessandro Palma
University of Rome “Tor Vergata”, Rome, Italy
A new web portal for exploring inter- and intra-cellular interactions in muscle regeneration

P-14
Dávid Fazekas
Eötvös Lóránd University, Budapest, Hungary
SignaLink 3, a tissue specific and extended multi-layered signaling network resource

Systems microbiology and therapy

P-15
Mohieddin Jafari
Pasteur Institute of Iran, Tehran, Iran
Stromal cell secretome reveals the mechanism underlying acquired doxorubicin resistance: a systems pharmacology approach

P-16
Dezső Módos
University of Cambridge, Cambridge, United Kingdom
Resistant Escherichia coli interactome identifies putative novel combinations to break antimicrobial resistance

P-17
Agatha Treveil
Earlham Institute, Norwich, United Kingdom
Investigating regulation of cellular functions in the gut by Bifidobacteria using network biology and organoid approaches

P-18
Hugo Samano-Sanchez
EMBL, Heidelberg, Germany
Bacterial mimicry of eukaryotic linear motifs

P-19
Padhmanand Sudhakar
Earlham Institute, Norwich, United Kingdom
An integrated computational analysis of the targeted interplay between bacterial pathogens and host autophagy

Speakers

Andrei Zinovyev
Institut Curie, France

Vera Van Noort
Uni Lueven, Belgium

Julio Saez-Rodriguez
RWTH-Aachen
University, Germany

Burkhard Rost
Technical University of
Munich, Munich, Germany

Photo: Eckert and Heddergott ©

Attila Remenyi
Inst. of Enzymology, Hungary

Natasa Przulj
UCL, UK

Evangelia Petsalaki
EMBl-EBI, UK

Balázs Papp
BRC, HAS, Hungary

Ruth Nussinov
National Cancer Inst., USA

Toby Gibson
EMBL, Germany

Jasmin Fisher
Univ. of Cambridge & Microsoft Research, UK

Federica Di Palma
Earlham Institute, UK

Andreas Bender
University of Cambridge, UK

Gary Bader
University of Toronto, Canada